Only the 3 adduct intermediate was observed in the formation

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steroids drugs Formation of the picramides is subject to general acid catalysis due to the poor leaving group ability of the ethoxide ion. Only the 3 adduct intermediate was observed in the formation of each picramide from the phenyl ether. The fact that the 1 adduct is not seen is attributed to the phenoxide ion being a weaker base and hence a much superior leaving group to the ethoxide ion. steroids drugs

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